MaterniT® 21 PLUS Testing
Convenient blood draws
Getting your blood drawn is easier than ever. It can be drawn at the Wilmington Health OB/GYN offices, allowing for convenient access to sample collection.
Genetic counseling
Patients with a positive test result will be offered counseling, and Integrated Genetics offers the largest national commercial network of genetic counselors to help inform and support patients.
A noninvasive blood test
With a blood draw from you as early as 11 weeks into your pregnancy, the MaterniT® 21 PLUS test can screen for certain chromosomal abnormalities that could affect your baby’s health and development, providing you with more information earlier in your pregnancy.
What it screens for—and why
Like most noninvasive prenatal tests (NIPT), MaterniT 21 PLUS screens for certain chromosomal abnormalities called trisomies, including trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome).
But it digs deeper, screening for certain sex chromosome aneuploidies (SCAs, abnormal numbers of X or Y chromosomes) and select microdeletions (missing parts of chromosomes).
While rare, these chromosomal abnormalities can have profound consequences in the life and health of your child. Detecting this information early can help your doctor recommend specialized care for you and your baby, before and after delivery. It also reveals the gender of the baby prior to the anatomy scan.
The MaterniT 21 PLUS test detects the following chromosomal abnormalities:
TRISOMIES
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Trisomy 16*
- Trisomy 22*
SCAS*
- 45,X (Turner syndrome)
- 47,XXY (Klinefelter syndrome)
- 47,XXX (Triple X syndrome)
- 47,XYY (XYY syndrome)
MICRODELETIONS
- 22q (DiGeorge syndrome)
- 11q (Jacobsen syndrome)*
- 5p (Cri-du-chat syndrome)*
- 8q (Langer-Giedion syndrome)*
- 1p36 deletion syndrome*
- 4p (Wolf-Hirschhorn syndrome)*
- 15q (Prader-Willi syndrome; Angelman syndrome)*
* Reported as an additional finding. Talk to your doctor about your options.
Why “noninvasive?”
There are many ways to get this information, including methods such as serum screens and diagnostic procedures such as amniocentesis.
As a noninvasive prenatal test, MaterniT 21 PLUS is different from both. It has higher detection rates than serum screening 1 (determined to be 97.9% positive predictive value for trisomy 21 in a high-risk cohort 2), and requires only a blood draw from the mother; amniocentesis requires withdrawing fluid from around the developing baby.
Most women who get the MaterniT 21 PLUS will screen negative for chromosomal abnormalities and may not require further testing.
However, any patient with a positive test result may be offered genetic counseling and/or diagnostic testing for confirmation of test results.
Clear results, delivered quickly
The test delivers clear positive or negative results for well known chromosomal abnormalities, such as trisomy 21 (Down syndrome), typically returned in around one – two weeks from your blood being drawn.
Also, if you’re carrying twins, MaterniT 21 PLUS can detect common chromosomal abnormalities in multiple gestation pregnancies.
Watch a short video to learn about the test: integratedgenetics.com/videos
If you have any questions, ask your provider at your next appointment or call:
Mayfaire V
6727 Parker Farm Drive
Wilmington, NC 28405
910-343-1031
Midtown
1124 Gallery Park Boulevard
Wilmington, NC 28412
910-343-1031
Hampstead
40 Ravenswood Road
Hampstead, NC 28443
910-343-1031
Note: This material is provided for general information purposes only. It is not intended as a substitute for medical advice and/or consultation with a physician or technical expert.
REFERENCES
1. Practice Bulletin No. 163 Summary. (2016). Obstetrics & Gynecology, 127(5), 979-981.
2. Porreco RP, Garite TJ, Maurel K et al. Noninvasive prenatal screening for fetal trisomies 21, 18, 13 and the common sex chromosome aneuploidies from maternal blood using massively parallel genomic sequencing of DNA. Am J Obstet Gynecol 2014;211:365.e1–12.
3. llumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/ verifi-prenatal-tests.html. Accessed August 15, 2018.